Table 3.

Postoperative delirium and opioid doses

	TMH group (n=20)	TN group (n=20)
Premedication
Number of patients	0 (0.0)	2 (10.0)
Mean midazolam dose (mg)	0	1.75
Intraoperative opioid
Total dose (mg)	21.67 (13.75–32.50)	16.67 (10.00–22.50)	(p=0.22)
Received intravenous morphine	2 (10.0)	1 (5.0)
Received intravenous fentanyl	10 (50.0)	14 (70.0)
Received intravenous oxycodone	9 (45.0)	7 (35.0)
Received intravenous tramadol	4 (20.0)	0 (0.0)
Received intravenous clonidine	0 (0.0)	2 (10.0)
Intrathecal morphine
Number of patients	5	2
Mean dose (μg)	220	350
Epidural analgesia
Number of patients	0	0
Blood glucose level
Glucose (mmol/L)	7.1 (7.0–7.1)	6.6 (6.4 to 6.7)	(p=0.33)
Preoperative CAM	0 (0.0–0.0)	0 (0.0–0.0)
Postoperative CAM	0 (0.0–0.0)	1.5 (0.0–3.0)
Presence of postoperative delirium	0 (0.0)	6 (30.0)	(p=0.02)

Data reported as median (IQR) or number (%).

Note some patients received two or more different intraoperative opioids.

Total dose of intraoperative opioid normalised to intravenous morphine equivalent.

CAM, Confusion Assessment Method; TMH, targeted mild hypercapnia; TN, targeted normocapnia.