Ment 1988.

Methods	Blinding of randomisation: yes Blinding of intervention: yes Blinding of outcome measurement: yes Complete (> 90%) follow‐up: yes
Participants	36 newborn infants, birthweight < 1250 grams. Excluded infant with IVH on pre‐study ultrasound examination.
Interventions	Indomethacin versus saline placebo. Indomethacin dosage: 3 doses (3 x 0.1 mg/kg), first dose 6 ‐ 12 hours of age, 24 hourly thereafter. Study medication stopped if IVH detected, abnormal bleeding, thrombocytopaenia, elevated plasma urea, or urine output <0.5 ml/kg/hr.
Outcomes	Death IVH PDA Renal function (electrolyte abnormality, urine output) Haemostasis (Platelet count, clinical bleeding)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Adequate
Allocation concealment?	Low risk	Adequate
Blinding? All outcomes	Low risk	Blinding of intervention ‐ yes Blinding of outcome measurement(s) ‐ yes
Incomplete outcome data addressed? All outcomes	Low risk	Complete (> 90%) follow‐up: yes