| Methods |
Blinding of randomisation: can't tell
Blinding of intervention: yes
Blinding of outcome measurement: yes
Complete (> 90%) follow‐up: yes |
| Participants |
30 newborn infants, birthweight < 1500 grams |
| Interventions |
IV prophylactic indomethacin vs. an equal volume of normal saline. Indomethacin dosage: 3 doses (3 x 0.2 mg/kg), first dose at 12 hours of age, 12 hourly thereafter |
| Outcomes |
Cerebral palsy at 2 years corrected age
Death
IVH
Symptomatic PDA
Evolving chronic lung disease (clinical signs, pCO2 > 60 mm Hg at 2 weeks of age)
NEC
ROP
Renal impairment |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Blinding?
All outcomes |
Low risk |
Blinding of intervention ‐ yes
Blinding of outcome measurement(s) ‐ yes |
| Incomplete outcome data addressed?
All outcomes |
Low risk |
Complete (> 90%) follow‐up: yes |
