Table 6.

[Ca²⁺]i oscillation for control, TRPV4-KD, Piezo1-KD, and Piezo2-KD stimulated with 18% CTS stimulation (mean ± standard deviation).

	18% CTS control (n = 37)	18% CTS TRPV4-KD (n = 42)	18% CTS Piezo1-KD (n = 45)	18% CTS Piezo2-KD (n = 38)
[Ca2+]i response rates (%)	23.55 ± 2.14	24.16 ± 2.37	24.03 ± 2.19	15.21 ± 1.28 ↓
Amplitude	10.06 ± 0.96	9.84 ± 0.87	9.35 ± 0.91	3.96 ± 0.34 ↓
Frequency (Peaks/min)	0.20 ± 0.02	0.21 ± 0.02	0.21 ± 0.02	0.14 ± 0.01 ↓

Note: Cell numbers examined for [Ca²⁺]i oscillation were 37 cells (control), 42 cells (TRPV4-KD), 45 cells (Piezo1-KD), and 38 cells (Piezo2-KD) for 18% CTS, respectively. Data are represented as the mean ± standard deviation of three independent experiments.

TRPV4: transient receptor potential vanilloid 4; CTS: cyclic tensile strains; KD: knockdown.