Table 1.
Healthy control subjects |
FRDA subjects |
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No. | Gender | Age at time of study | FXN mRNA expression (±std dev) | No. | Gender | Age at time of study | Age of disease onset | Number of GAA repeats in the less expanded allele | Total ICARS SCORE | FXN mRNA expression (±std dev) |
1 | F | 19 | 1 ± 0.11 | 1 | F | 13 | 9 | 830 | 16 | 0.1 ± 0.01 |
2 | M | 19 | 1.25 ± 0.23 | 2 | M | 29 | 16 | 360 | 29 | 0.16 ± 0.02 |
3 | M | 19 | 2.35 ± 0.49 | 3 | M | 24 | 11 | 625 | 59 | 0.17 ± 0.03 |
4 | F | 19 | 0.9 ± 0.15 | 4 | F | 18 | 8 | 621 | 10 | 0.26 ± 0.02 |
5 | F | 19 | 1.24 ± 0.37 | 5 | F | 27 | 3 | 560 | 39 | 0.17 ± 0.02 |
6 | F | 26 | 1.24 ± 0.06 | 6 | M | 23 | 8 | 760 | 67 | 0.17 ± 0.05 |
7 | F | 23 | 1.23 ± 0.06 | 7 | F | 16 | 12 | 600 | 19 | 0.3 ± 0.01 |
Note: FXN mRNA expression was arbitrarily set to 1 in control subject #1, then all FXN mRNA expression values were referred to that sample.