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. 2019 Jul 11;47(4):1013–1027. doi: 10.1042/BST20180348

Figure 4. SAMHD1 catalytic site accommodates dNTPs and dNTP analogues.

Figure 4.

(A–F) Nucleotide coordination in the catalytic site of the human SAMHD1 HD domain. (A) WT SAMHD1 with dGTPαS (PDB: 4BZC) [85]. (B) H206R/D207N SAMHD1 with dATP (PDB: 4QG1) [88]. (C) H206R/D207N SAMHD1 with TTP (PDB: 4TNZ) [87]. (D) WT SAMHD1 with dCTP (PDB: 4RXR) [95]. (E) WT SAMHD1 with ddGTP (PDB: 5AO1) [77]. (F) H206R/D207N SAMHD1 with gemcitabine-TP (Gem-TP) (PDB: 6DW5) [101]. Nucleotides are shown in stick representation with Cα atoms in pink. Manganese (purple), magnesium (green) and iron (brown) metal ions are represented as spheres.