Skip to main content
. Author manuscript; available in PMC: 2020 Feb 27.
Published in final edited form as: Science. 2018 Jun 22;360(6395):eaar6910. doi: 10.1126/science.aar6910

Fig. 1. Amino acid residues in the single BIR domain of human survivin (BIRC5) required for binding S12 are not well conserved in either of the BIR domains of AfBIR1.

Fig. 1.

Human survivin (NP_001159) is aligned using ClustalW to both BIR domains of A. fumigatus BIR1 (XP_752777). Disruption of either Phe86 or Val89 (red frames) in survivin inhibits S12 binding; asterisks mark residues forming the interface between survivin dimers (10). Amino acid abbreviations: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; Y, Tyr.