Fig. 6.

Guadecitabine similarly reduces E0771 tumor size and improves effectiveness of AIT. E0771 tumor-bearing mice were treated with guadecitabine on days 3–6. a Time-course experiment showing E0771 tumor growth in WT C57Bl/6 mice. b E0771 tumor progression following AIT treatment as in Fig. 5. c AUC quantification of tumor growth following combination therapy. Significance determined using ANOVA with Sidak’s (a) or Tukey’s (c) multiple comparison test. Error bars represent SEM. *:p value< 0.0332; **:p value< 0.0021; ***:p value< 0.0002; ****:p value< 0.00001