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. 2020 Feb 27;16:4. doi: 10.1186/s12993-020-00166-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Effects of Naringin oncaspase-3, caspase-8,Bax,Bcl-2mRNA expression in the hippocampus of CCL2-treated rats. Quantitative real-time PCR analysis of messenger (m)RNA levels. Relative expression of: a The caspase-3 mRNA. b The caspase-8 mRNA. c The Bax mRNA expression. d The Bcl-2 mRNA. qPCR analysis showed increased expression of caspase-3, caspase-8, Bax mRNA while decreased expression of Bcl-2 in hippocampus of CCL2 rats, This result showing that Naringin significantly decreased expression of caspase-3, caspase-8, Bax mRNA while significantly increased Bcl-2 mRNA in CCL2 group rat.The experiments were repeated four times independently. Values are expressed as mean ± SEM, n = 4 (^#P < 0.05, ^##P < 0.01 vs sham, ^*P < 0.05, ^**P < 0.01 vs CCL2)