Table 1.
Patient’s demographics and tumor characteristics and association of ALKBH5 levels with clinicopathological features
| Characteristics | No. of patients, N = 60 (%) | P value |
|---|---|---|
| Patients Parameter | ||
| Age (years) | 0.871 | |
| Average [range] | 53 [30–81] | |
| < 53 | 20 (33.3) | |
| ≥ 53 | 40 (66.7) | |
| Gender | 0.714 | |
| Male | 32 (53.3) | |
| Female | 28 (46.7) | |
| Smoking history | ||
| Smoker | 35 (58.3) | 0.12 |
| Non-smoker | 25 (41.7) | |
| Tumor Characteristics | ||
| Tumor size (cm) | 0.009** | |
| < 4 | 10 (16.7) | |
| ≥ 4 | 50 (83.3) | |
| Differentiation | 0.044* | |
| Poor | 41 (68.3) | |
| Well-moderate | 19 (31.7) | |
| Lymph node metastasis | 0.014* | |
| N- | 9 (15.0) | |
| N+ | 51 (85.0) | |
| Distant metastasis | 0.008** | |
| M- | 8 (13.3) | |
| M+ | 52 (86.7) | |
| Expression of ALKBH5 | ||
| Protein level | ||
| high | 2 (3.3) | 0.086 |
| median | 8 (13.3) | 0.078 |
| low | 50 (83.4) | 0.002** |
| mRNA level | ||
| high | 3 (5.0) | 0.074 |
| median | 9 (15.0) | 0.063 |
| low | 48 (80.0) | 0.001** |
| Expression of YAP | ||
| Protein level | ||
| high | 46 (76.6) | 0.008** |
| median | 9 (15.5) | 0.062 |
| low | 5 (7.9) | 0.865 |
| mRNA level | ||
| high | 48 (80.0) | 0.005** |
| median | 8 (13.3) | 0.084 |
| low | 4 (6.7) | 0.754 |
Differences between experimental groups were assessed by Student’s t-test or one-way analysis of variance. Data represent mean ± SD. *p < 0.05; **p < 0.01