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. 2020 Feb 26;13:22. doi: 10.1186/s13048-020-00623-w

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Granulosa cells from FMR1 premutation female carriers demonstrating co-localization of FMRpolyG and ubiquitin. a Fixated and stained granulosa cells from FMR1 premutation female carriers (FMR PM #1–3) displayed FMRpolyG expression and accumulation in ubiquitin-positive cytoplasmic inclusions. Granulosa cells from a non-carrier woman did not show any formation of FMRpolyG or ubiquitin inclusion bodies (CTL) Bar 10 μm. b Immunoblotting using anti-FMRpolyG revealed expression in granulosa cells of FMR1 premutation carriers (59 and 65 CGG repeats respectively) and none in granulosa cells from a non-carrier (CTL)