Burry 1989.
Methods | Randomised trial. Double‐blind, double‐dummy design. No details of randomisation. No details of allocation concealment. Attrition 2/53 details in quality table. | |
Participants | American study of 53 women. Age 23‐38 years. All women complained of infertility, pain or both. Laparoscopic diagnosis was made within 3 months prior to study. Women were excluded if they had received medical therapy for endometriosis within preceding 6 months. 62% of the women had stage III and IV disease. | |
Interventions | Danazol 800 mg daily (n=10) PO + placebo
versus
danazol 600 mg daily (n=8) PO + placebo
versus
nafarelin 800 µg daily (n=10) IN + placebo
versus
nafarelin 400 µg daily (n=25) IN + placebo. Women were followed up at 2, 4 and 6 months after treatment. |
|
Outcomes | Weight, adverse events, compliances, change in symptoms, haematological analysis, pregnancy. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | 'Randomly assigned' no further details. |
Allocation concealment? | Unclear risk | Unclear, no further details. |
Blinding? All outcomes | Low risk | Double‐blind double‐dummy design with both patients and investigators being blind to treatment. |
Incomplete outcome data addressed? All outcomes | Low risk | One women from danazol 800 mg withdrew because of severe headaches, one woman from nafarelin 800 µg withdrew because of mood swings. |
Free of selective reporting? | High risk | Not followed up to live birth. |