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. 2007 Jul 18;2007(3):CD000155. doi: 10.1002/14651858.CD000155.pub2

Burry 1989.

Methods Randomised trial. Double‐blind, double‐dummy design. No details of randomisation. No details of allocation concealment. Attrition 2/53 details in quality table.
Participants American study of 53 women. Age 23‐38 years. All women complained of infertility, pain or both. Laparoscopic diagnosis was made within 3 months prior to study. Women were excluded if they had received medical therapy for endometriosis within preceding 6 months. 62% of the women had stage III and IV disease.
Interventions Danazol 800 mg daily (n=10) PO + placebo 
 versus 
 danazol 600 mg daily (n=8) PO + placebo 
 versus 
 nafarelin 800 µg daily (n=10) IN + placebo 
 versus 
 nafarelin 400 µg daily (n=25) IN + placebo.
Women were followed up at 2, 4 and 6 months after treatment.
Outcomes Weight, adverse events, compliances, change in symptoms, haematological analysis, pregnancy.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk 'Randomly assigned' no further details.
Allocation concealment? Unclear risk Unclear, no further details.
Blinding? 
 All outcomes Low risk Double‐blind double‐dummy design with both patients and investigators being blind to treatment.
Incomplete outcome data addressed? 
 All outcomes Low risk One women from danazol 800 mg withdrew because of severe headaches, one woman from nafarelin 800 µg withdrew because of mood swings.
Free of selective reporting? High risk Not followed up to live birth.