Table 1.

post-NAC status of GR, Sgk1, NDRG1 and its correlation with clinicopathological variables

Variable		n	post-NAC GR expression		P	post-NAC Sgk1 expression		P	post-NAC NDRG1 expression		P
			High	Low		High	Low		High	Low
Age	≧65y.o	62	32	30		35	27		22	40
	< 65y.o	36	20	16	p = 0.706	18	18	p = 0.537	16	20	p = 0.380
Gender	Male	83	43	40		48	35		32	41
	Female	15	9	6	p = 0.559	5	10	p = 0.080	6	9	p = 0.915
pTa	pT1a~pT1b	28	12	16		9	19		1	27
	pT2~pT4b	70	40	30	p = 0.201	44	26	p = 0.006*	37	33	p < 0.001*
pNa	pN0	29	14	15		7	22		9	20
	pN1~N3	69	38	31	p = 0.539	46	23	p < 0.001*	29	40	p = 0.308
cMa	cM0	94	50	44		49	45		36	58
	cM1	4	2	2	p = 0.900	4	0	p = 0.060	2	2	p = 0.638
pStagea	pStageI,II	40	20	20		11	29		9	31
	pStageIII,IV	58	32	26	p = 0.614	42	16	p < 0.001*	29	29	p = 0.006*
Tumor differentiationa	well,moderate	84	47	37		44	40		33	51
	poor	10	4	6	p = 0.339	8	2	p = 0.097	5	5	p = 0.517
	Unclassifiable	4	1	3		1	3		0	4
Lymphatic invasion	Absence	29	14	15		9	20		9	20
	Presence	69	38	31	p = 0.538	44	25	p = 0.003*	29	40	p = 0.308
Vessel invasion	Absence	18	5	13		6	12		3	15
	Presence	80	47	33	p = 0.016*	47	33	p = 0.051	35	45	p = 0.033*
RECIST gradeb	CR/PR	28	12	16		10	18		8	20
	SD/PD	57	34	23	p = 0.144	38	19	p = 0.007*	28	29	p = 0.072
	Indeterminate	13	6	7		5	8		2	11
Histopathological tumor regression gradec	Grade0~1a	63	37	26		39	24		27	36
	Grade1b~ 2	35	15	20	p = 0.131	14	21	p = 0.037*	11	24	p = 0.267
Total		98	52	46		53	45		38	60

* Statistical significance

^a Tumor-node-metastasis (TNM) classification based on the 8th edition of the TNM classification of malignant tumors

^b New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1)

^c Histopathological features based on the Japanese Classification of Esophageal Cancer, 11th edition (Japan Esophageal Society 2015)