Fig. 4.

Fold enrichment in human metabolic pathways of parasite-infected erythrocytes at 0–8 h, 16–24 h, and 32–40 h. MetaboAnalyst [10], which takes human metabolome database identifiers as input, was used to compute fold enrichment. Of the pathways in the small molecule pathway database library [11] of normal human metabolic pathways, only those that contained at least five metabolites were used. Asterisks indicate fold-enrichments with an adjusted criterion of p ≤ 0.01 [44]. BCAA branched-chain amino acid, CoA co-enzyme A, FA fatty acid, PPP pentose phosphate pathway, TCA tricarboxylic acid