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. 2020 Feb 26;21:51. doi: 10.1186/s13059-020-01956-x

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — α-helical structure is critical for the Cas9-inhibiting activity of G8P_PD. a Alanine mutations at positions 6–11 abolish the inhibitory activity of G8P_PD. The results are shown as mean ± SD (n = 3). The arrow denotes cleavage products. b Structure of G8P_PD peptide (PDB entry 2MJZ), displayed by PyMOL. Residues 6–11 are shown as stick. c CD spectra of f1 G8P_PD WT and mutant 2