Table 1.
Patient characteristics | Colistin (n = 40) | Colistin plus meropenem (n = 31) | p |
---|---|---|---|
Age, years | 64.57 ± 16.24 | 70.06 ± 12.01 | 0.12 |
Sex, male | 22 (55.0%) | 20 (64.5%) | 0.41 |
Comorbid condition | |||
Diabetes mellitus | 16 (40.0%) | 12 (38.7%) | 1.00 |
Cardiovascular disease | 8 (20.0%) | 9 (29.0%) | 0.37 |
Chronic lung disease | 11 (27.5%) | 9 (29.0%) | 0.88 |
Renal impairment | 12 (30.0%) | 10 (32.3%) | 0.83 |
Chronic liver disease | 8 (20.0%) | 3 (9.7%) | 0.32 |
Cerebrovascular disease | 17 (42.5%) | 13 (41.9%) | 0.96 |
Malignancy | 6 (15.0%) | 9 (29.0%) | 0.15 |
Charlson Comorbidity Index | 3.20 ± 1.77 | 3.32 ± 1.44 | 0.75 |
Pitt bacteremia score | 4.05 ± 2.51 | 3.93 ± 2.30 | 0.84 |
Steroid/immunosuppressant use | 5 (12.5%) | 8 (25.8%) | 0.15 |
Recent surgery | 11 (27.5%) | 10 (32.3%) | 0.66 |
CVC | 36 (90.0%) | 28 (90.3%) | 0.96 |
Type of infection | |||
Pneumonia | 15 (37.5) | 16 (51.6) | 0.33 |
CRI | 17 (42.5%) | 10 (32.3) | 0.46 |
SSTI | 4 (10.0) | 3 (9.7) | 1.00 |
IAI | 2 (5.0) | 1 (3.2) | 1.00 |
UTI | 0 (0) | 1 (3.2) | 0.43 |
PB | 1 (2.5) | 0 (0) | 1.00 |
CNS infection | 1(2.5) | 0 (0) | 1.00 |
ABs before colistin administration | 15 (37.5) | 5 (16.1) | 0.06 |
ABs during colistin and/or meropenem administration | 8 (20.0) | 3 (9.7) | 0.32 |
Data are presented as mean ± standard deviation, SD for continuous variables and as n (%) of patient s for categorical variables. CVC, central venous catheter; CRI, central line associated infection; UTI, urinary tract infection; SSTI, skin and soft tissue infection; IAI, intra-abdominal infection; PB, primary bacteremia; CNS, central nervous system, ABs, antibiotics other than colistin or meropenem.