Table 1.
List of the top 100 most influential articles on allergic rhinitis.
| Rank | Title | Journal | Year | First Author | Institute | Citation | Class |
|---|---|---|---|---|---|---|---|
| 1 | Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) | Allergy | 2008 | Bousquet J | Hospital Arnaud de Villeneuve | 2130 | review |
| 2 | Allergic rhinitis and its impact on asthma | Journal of Allergy and Clinical Immunology | 2001 | Bousquet J | Hospital Arnaud de Villeneuve | 1624 | review |
| 3 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision | Journal of Allergy and Clinical Immunology | 2010 | Brozek Jan L | McMaster University | 684 | review |
| 4 | Prevalence and rate of diagnosis of allergic rhinitis in Europe | European Respiratory Journal | 2004 | Bauchau V | UCB Pharma S.A. | 499 | 4 |
| 5 | Immunolocalization of cytokines in the nasal-mucosa of normal and perennial rhinitic subjects - the mast-cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation | Journal of Immunology | 1993 | Bradding P | Southampton University | 470 | technology |
| 6 | Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis | Allergy | 2005 | Wilson DR | University Hospital Birmingham | 459 | 1 |
| 7 | Consensus statement on the treatment of allergic rhinitis | Allergy | 2000 | van Cauwenberge P | Ghent University Hospital | 396 | review |
| 8 | Allergic rhinitis: Definition, epidemiology, detection, and pathophysiology, diagnosis | Journal of Allergy and Clinical Immunology | 2001 | Skoner DR | University of Pitts- burgh School of Medicine | 384 | review |
| 9 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis | New England Journal of Medicine | 2006 | Creticos Peter S | Johns Hopkins University School of Medicine | 372 | 2 |
| 10 | Intranasal corticosteroids versus oral H-1, receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials | British Medical Journal | 1998 | Weiner JM | Monash University | 365 | 1 |
| 11 | Assessment of quality-of-life in patients with perennial allergic rhinitis with the French version of the SF-36 health-status questionnaire | Journal of Allergy and Clinical Immunology | 1994 | Bousquet J | Hospital Arnaud of Villeneuve | 334 | 4 |
| 12 | Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2007 | Didie Alain | Larrey Hospital | 333 | 2 |
| 13 | Epidemiology of physician-diagnosed allergic rhinitis in childhood | Pediatrics | 1994 | Wright AL | The Steele Memorial Children's Research Center | 305 | 4 |
| 14 | Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge - characterization of Eosinophil and mast-cell mediators | American Review of Respiratory Disease | 1991 | Sedgwick JB | University of Wisconsin | 288 | technology |
| 15 | The burden of allergic rhinitis | Allergy and Asthma Proceedings | 2007 | Nathan Robert A. | University of Colorado Health Sciences Center | 287 | review |
| 16 | Seasonal allergic rhinitis and antihistamine effects on children’s learning | Annals of Allergy | 1993 | Vuurman EF | University of Limburg | 267 | 4 |
| 17 | Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs | Journal of Allergy and Clinical Immunology | 2012 | Bousquet J | Hospital Arnaud of Villeneuve | 262 | review |
| 18 | Drug-therapy - allergic rhinitis | New England Journal of Medicine | 1991 | Naclerio RM | Johns Hopkins University School of Medicine | 252 | review |
| 19 | Allergen injection immunotherapy for seasonal allergic rhinitis | Cochrane Database of Systematic Reviews | 2007 | Calderon MA | Royal Brompton Hospital | 246 | 1 |
| 20 | Obstructive apneas during sleep in patients with seasonal allergic rhinitis | American Review of Respiratory Disease | 1982 | McNicholas WT | Queen Elizabeth Hospital | 245 | 3 |
| 21 | Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients | American Journal of Respiratory and Critical Care Medicine | 2000 | Braunstahl GJ | Erasmus University Medical Center Rotterdam | 244 | 3 |
| 22 | Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilon RI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells | Journal of Clinical Investigation | 1997 | Pawankar R | Juntendo University School of Medicine | 244 | technology |
| 23 | Inhibition of mediator release in allergic rhinitis by pretreatment with topical glucocorticosteroids | New England Journal of Medicine | 1987 | Pipkorn U | Johns Hopkins University School of Medicine | 244 | 2 |
| 24 | A survey of the burden of allergic rhinitis in Europe | Allergy | 2007 | Canonica GW | University of Genoa | 238 | 4 |
| 25 | Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials | Annals of Allergy Asthma & Immunology | 2006 | Penagos Martin | University of Genoa | 236 | 1 |
| 26 | Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin-tests | Lancet | 1975 | Huggins KG | Middlesex Hospital Medical School | 231 | 3 |
| 27 | Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis | Journal of Allergy and Clinical Immunology | 1997 | Casale TB | University of Iowa | 229 | 3 |
| 28 | Effect of omalizumab on symptoms of seasonal allergic rhinitis - A randomized controlled trial | Jama-Journal of the American Medical Association | 2001 | Casale TB | Creighton University | 223 | 2 |
| 29 | Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2000 | Adelroth E | Umea University Hospital | 219 | 2 |
| 30 | Concomitant montelukast and loratadine as treatment for seasonal allergic rhinitis: A randomized, placebo-controlled clinical trial | Journal of Allergy and Clinical Immunology | 2000 | Meltzer EO | Allergy and Asthma Medical Group and Research Center (San Diego) | 217 | 2 |
| 31 | Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey | Journal of Allergy and Clinical Immunology | 2009 | Meltzer EO | Allergy and Asthma Medical Group and Research Center (San Diego) | 215 | 4 |
| 32 | Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2002 | Kuehr J | University Children’s Hospital | 209 | 2 |
| 33 | Allergic rhinitis | Lancet | 2011 | Greiner Alexander N | Allergy and Asthma Medical Group and Research Center (San Diego) | 207 | technology |
| 34 | Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2006 | Casale TB | the Creighton University School of Medicine | 205 | 2 |
| 35 | A cost of illness study of allergic rhinitis in the United States | Journal of Allergy and Clinical Immunology | 1997 | Malone DC | University of Colorado Health Sciences Center | 202 | 4 |
| 36 | Airway hyperresponsiveness in allergic rhinitis - a risk factor for asthma | Chest | 1987 | Braman SS | Rhode Island Hospital and Brown University | 201 | 4 |
| 37 | Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: Case-control study | Journal of Allergy and Clinical Immunology | 2007 | Walker Samantha | University of Edinburgh | 199 | 4 |
| 38 | Immunohistology of the nasal-mucosa in seasonal allergic rhinitis - increases in activated eosinophils and epithelial mast-cells | Journal of Allergy and Clinical Immunology | 1992 | Bentley AM | Royal Brompton Hospital | 198 | technology |
| 39 | Quality of life in adults and children with allergic rhinitis | Journal of Allergy and Clinical Immunology | 2001 | Meltzer EO | The Allergy and Asthma Medical Group and Research Center | 196 | review |
| 40 | Allergic rhinitis and its impact on asthma update: Allergen immunotherapy | Journal of Allergy and Clinical Immunology | 2007 | Passalacqua Giovanni | University of Genoa | 194 | review |
| 41 | Absence of growth retardation in children with perennial allergic rhinitis after one year of treatment with mometasone furoate aqueous nasal spray | Pediatrics | 2000 | Schenkel EJ | Easton | 185 | 2 |
| 42 | Nasal congestion secondary to allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids | Journal of Allergy and Clinical Immunology | 1998 | Craig TJ | Penn State University | 184 | 3 |
| 43 | Severity and impairment of allergic rhinitis in patients consulting in primary care | Journal of Allergy and Clinical Immunology | 2006 | Bousquet J | Hospital Arnaud of Villeneuve | 167 | 3 |
| 44 | Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial performed in the spring | Clinical and Experimental Allergy | 2002 | Philip G | Merck Research Laboratories | 167 | 2 |
| 45 | Low-dose sublingual therapy in patients with allergic rhinitis due to house dust mite | Clinical Allergy | 1986 | Scadding GK | Middlesex Hospital Medical School | 163 | 3 |
| 46 | Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness | European Respiratory Journal | 1999 | Henriksen AH | Norwegian University of Science and Technology | 161 | 3 |
| 47 | Epidemiological characterization of the intermittent and persistent types of allergic rhinitis | Allergy | 2005 | Bauchau V | UCB Pharma S.A | 148 | 4 |
| 48 | Economic impact and quality-of-life burden of allergic rhinitis | Current Medical Research and Opinion | 2004 | Schoenwetter WF | Park Nicollet Clinic | 148 | review |
| 49 | Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective | Current Medical Research and Opinion | 2006 | Lamb Charles | PCA Occupational Medicine | 146 | 4 |
| 50 | Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis | Journal of Allergy and Clinical Immunology | 2004 | Bachert C | Ghent university Hospital | 146 | 2 |
| 51 | Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group | Clinical and Experimental Allergy | 2005 | Bousquet J | Hospital Arnaud of Villeneuve | 142 | 4 |
| 52 | Prevalence, classification and perception of allergic and nonallergic rhinitis in Belgium | Allergy | 2006 | Bachert C | Ghent University Hospital | 141 | 4 |
| 53 | The economic burden of allergic rhinitis - A critical evaluation of the literature | Pharmacoeconomics | 2004 | Reed SD | Duke University Medical Center | 140 | review |
| 54 | Efficacy and tolerability of montelukast alone or in combination with loratadine in seasonal allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial performed in the fall | Annals of Allergy Asthma & Immunology | 2002 | Nayak AS | University of Illinois | 138 | 2 |
| 55 | Once daily intranasal fluticasone propionate (200 mu g) reduces nasal symptoms and inflammation but also attenuates the increase in bronchial responsiveness during the pollen season in allergic rhinitis | Journal of Allergy and Clinical Immunology | 1996 | Foresi A | Serbizio di Fisiopatologia Respiratoria | 138 | 2 |
| 56 | Leukotriene receptor antagonists for allergic rhinitis: A systematic review and meta-analysis | American Journal of Medicine | 2004 | Wilson AM | McMaster University | 137 | 1 |
| 57 | Intranasal corticosteroids versus topical H-1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis | Annals of Allergy Asthma & Immunology | 2002 | Yanez A | Hospital Aerona ´utico Central | 134 | 1 |
| 58 | The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis | American Journal of Respiratory Cell and Molecular Biology | 1992 | Montefort S | Southampton General Hospital | 134 | technology |
| 59 | Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis | Annals of Allergy Asthma & Immunology | 2003 | Chervinsky P | Northeast Medical Research Associates | 133 | 2 |
| 60 | The leukotriene D-4-receptor antagonist, ICI-204,219, relieves symptoms of acute seasonal allergic rhinitis | American Journal of Respiratory and Critical Care Medicine | 1995 | Donnelly AL | University of Iowa College of Medicine | 133 | 2 |
| 61 | A survey of the burden of allergic rhinitis in the USA | Allergy | 2007 | Schatz M | Kaiser Permanente Medical Center | 131 | 4 |
| 62 | Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis | Journal of Immunology | 2005 | Takhar P | King’s College London | 131 | technology |
| 63 | Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 1999 | Howarth PH | Southampton General Hospital | 131 | 2 |
| 64 | Allergic rhinitis and its consequences on quality of sleep - An unexplored area | Archives of Internal Medicine | 2006 | Leger Damien | Assistance Public Hospital of Paris | 127 | 4 |
| 65 | Validation of the classification of ARIA (allergic rhinitis and its impact on asthma) | Allergy | 2003 | Demoly P | Hospital Arnaud de Villeneuve | 127 | 4 |
| 66 | Allergen-induced release of sulfidopeptide leukotrienes (SRS-A) and LTB4 in allergic rhinitis | Allergy | 1985 | Shaw RJ | Brompton Hospital | 127 | technology |
| 67 | Nasal nitric oxide is increased in allergic rhinitis | Clinical and Experimental Allergy | 1997 | Arnal JF | Hospital Rangueil | 124 | technology |
| 68 | Evaluation of impermeable covers for bedding in patients with allergic rhinitis | New England Journal of Medicine | 2003 | Terreehorst I | Erasmus Medical Center | 123 | 2 |
| 69 | The role of leukotriene-D4 in allergic rhinitis | Annals of Allergy | 1988 | Okuda M | Nippon Medical School | 123 | technology |
| 70 | Quality of life in patients with allergic rhinitis | Annals of Allergy Asthma & Immunology | 2000 | Thompson AK | McMaster University | 122 | review |
| 71 | Prevalence of allergic rhinitis in the United States | Journal of Allergy and Clinical Immunology | 1997 | Nathan RA | Colorado Springs | 122 | 4 |
| 72 | An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment | Journal of Allergy and Clinical Immunology | 2005 | Meltzer EO | Allergy and Asthma Medical Group and Research Center (San Diego) | 121 | 2 |
| 73 | The cost of productivity losses associated with allergic rhinitis | American Journal of Managed Care | 2000 | Crystal-Peters J | Washington | 120 | 4 |
| 74 | Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa | American Journal of Respiratory and Critical Care Medicine | 2001 | Braunstahl GJ | Erasmus University Medical Center Rotterdam | 119 | 3 |
| 75 | Clinical Practice Guideline: Allergic Rhinitis | Otolaryngology-Head and Neck Surgery | 2015 | Seidman Michael D | Henry Ford West Bloomfield Hospital West Bloomfield | 118 | review |
| 76 | Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial | Allergy | 2003 | Bousquet J | Hospital Arnaud de Villeneuve | 115 | 2 |
| 77 | Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis | Clinical and Experimental Allergy | 2000 | Van Cauwenberge P | Ghent University Hospital | 115 | 2 |
| 78 | Seasonal and perennial allergic rhinitis: is this classification adherent to real life? | Allergy | 2005 | Ciprandi G | S. Martino Hospital | 114 | 4 |
| 79 | Allergic rhinitis: A disease remodeling the upper airways? | Journal of Allergy and Clinical Immunology | 2004 | Bousquet J | Hospital Arnaud de Villeneuve | 114 | review |
| 80 | Breathing disorders in sleep associated with microarousals in patients with allergic rhinitis | Acta Oto-Laryngologica | 1981 | Lavie P | Rothschild University Hospital | 114 | 4 |
| 81 | A placebo-controlled trial of immunotherapy with 2 extracts of Dermatophagoides pteronyssinus in allergic rhinitis, comparing clinical outcome with changes in antigen-specific IgE, IgG, and IgG subclasses | Journal of Allergy and Clinical Immunology | 1990 | McHugh SM | University of Cambridge Clinical School | 113 | 2 |
| 82 | Allergic rhinitis: Direct and indirect costs | Allergy and Asthma Proceedings | 2010 | Blaiss Michael S | University of Tennessee Health Science Center | 112 | review |
| 83 | Inflammatory mediators in allergic rhinitis | Journal of Allergy and Clinical Immunology | 2004 | Gelfand Erwin W | National Jewish Medical and Research Center | 112 | review |
| 84 | Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis | European Respiratory Journal | 2000 | Polosa R | University of Catania | 112 | 4 |
| 85 | Learning impairment and allergic rhinitis | Allergy and Asthma Proceedings | 1996 | Simons FER | University of Manitoba | 112 | review |
| 86 | Plasma kallikrein during experimentally induced allergic rhinitis - role in kinin formation and contribution to tameesterase activity in nasal secretions | Journal of Immunology | 1986 | Baumgarten CR | The Johns Hopkins University School of Medicine | 111 | technology |
| 87 | Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2002 | Pullerits T | Göteborg University | 110 | 2 |
| 88 | Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis | Clinical and Experimental Allergy | 2001 | Wilson AM | University of Dundee | 110 | 3 |
| 89 | Different effects of nasal and bronchial glucocorticosteroid administration on bronchial hyperresponsiveness in patients with allergic rhinitis | American Review of Respiratory Disease | 1992 | Aubier M | Hospital Bichat | 110 | 3 |
| 90 | Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever | Journal of Allergy and Clinical Immunology | 2012 | Hatzler Laura | Charite University Medical Centre | 108 | 4 |
| 91 | Requirements for medications commonly used in the treatment of allergic rhinitis - European Academy of Allergy and Clinical Immunology (EAACI) allergic rhinitis and its impact on asthma (ARIA) | Allergy | 2003 | Bousquet J | Hospital Arnaud de Villeneuve | 107 | review |
| 92 | Overview of comorbid associations of allergic rhinitis | Journal of Allergy and Clinical Immunology | 1997 | Spector SL | University of California | 106 | review |
| 93 | Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series | British Medical Journal | 2000 | Taylor MA | Glasgow Royal Infirmary | 104 | 2 |
| 94 | Lower airways remodeling in nonasthmatic subjects with allergic rhinitis | Laboratory Investigation | 1996 | Chakir J | University Laval | 104 | 4 |
| 95 | Changes in daytime sleepiness, quality of life, and objective sleep patterns in seasonal allergic rhinitis: A controlled clinical trial | Journal of Allergy and Clinical Immunology | 2004 | Stuck BA | University Hospital Mannheim | 103 | 4 |
| 96 | Treatment of perennial allergic rhinitis with lactic acid bacteria | Pediatric Allergy and Immunology | 2004 | Wang MF | China Medical University Hospital | 103 | 2 |
| 97 | Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients | European Respiratory Journal | 2000 | KleinJan A | Erasmus University Medical Centre Rotterdam | 103 | 4 |
| 98 | A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology | Journal of Allergy and Clinical Immunology | 1990 | Meltzer EO | Allergy and Asthma Medical Group and Research Center (San Diego) | 103 | 4 |
| 99 | Local allergic rhinitis: Concept, pathophysiology, and management | Journal of Allergy and Clinical Immunology | 2012 | Rondon Carmen | Carlos Haya Hospital | 102 | review |
| 100 | Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2007 | Kaiser Harold B | Minneapolis | 102 | 2 |