Table 4:

Associations between mental disorders and psychiatric medication use with long-term change in mental and physical health-related quality of life, independent of weight change, following Roux-en-Y gastric bypass.

	Long-term pre-to post-surgery change
	SF-36 Mental Component Summary score				SF-36 Physical Component Summary score
	B (95% CI)a		DF	P	B (95% CI)a	DF	P
Any mood (Ref=no history)				<0.001			0.15
Pre-surgery history only	−7.01 (−11.34,−2.67)		68.2		4.11 (−0.81,9.03)	53
Post-surgery	−16.73 (−22.08,−11.37)		124		4.78 (−0.96,10.53)	87.8
Any eating disorder(Ref=no history)				0.07			0.72
Pre-surgery history or post-surgery	−5.00 (−10.39,0.40)		60.5		1.04 (−4.83,6.92)	48.7
Any psychiatric medication (Ref=no useb)				0.60			0.89
Pre-surgery only	−1.81 (−10.64,7.02)		92.4		−2.15 (−11.14,6.84)	67.6
Post-surgery	1.69 (−2.73,6.10)		69.2		−0.70 (−5.69,4.29)	54.4

Acronyms: SF-36, Short-Form Health Survey.

^aEstimated pre- to post-surgery change in SF-36 score in years 4–7 post-surgery associated with the indicated psychiatric variable, after adjustment for the other psychiatric variables, pre-surgery factors related to missing follow-up data (i.e. site and age), and sex, race, pre-surgery body mass index and pre-surgery mental component summary (MCS) or physical component summary (PCS) score, respectively, and % weight change from surgery with time entered as a fixed effect. When mood disorder was replaced by anxiety disorder, the estimate (95% CI) for change in MCS score was −5.76 (−10.26, −1.26) for pre-history only and −15.46 (−20.72, −10.2) for post-surgery (p<.001); the estimate (95% CI) for change in PCS score was 4.41 (−0.82, 9.64) for pre-history only and 4.94 (−0.76, 10.64) for post-surgery (p=.14). A negative value indicates less of an improvement or a decrease in the score. N=70 of 104 RYGB participants.

^bBased on current medication use at pre- and post-surgery assessments. Pre-surgery history of medication use not measured.