Summary of findings 3. Once daily dosing versus conventional dosing for induction of remission in ulcerative colitis.
| Once daily dosing versus conventional dosing for induction of remission in ulcerative colitis | ||||||
| Patient or population: Patients with active mild to moderate ulcerative colitis Settings: Outpatients Intervention: Once daily dosing versus conventional dosing | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | OD versus conventional dosing | |||||
|
Failure to induce global or clinical remission |
477 per 10001 | 448 per 1000 (396 to 510) | RR 0.94 (0.83 to 1.07) | 944 (4 studies) | ⊕⊕⊕⊕ high | |
|
Failure to induce clinical improvement |
458 per 10001 | 398 per 1000 (311 to 504) | RR 0.87 (0.68 to 1.10) | 358 (2 studies) | ⊕⊕⊕⊝ moderate2 | |
| Failure to adhere to medication regimen | 139 per 10001 | 189 per 1000 (89 to 398) | RR 1.36 (0.64 to 2.86) | 358 (2 studies) | ⊕⊕⊝⊝ low3 | |
| Adverse events | 374 per 10001 | 329 per 1000 (273 to 400) | RR 0.88 (0.73 to 1.07) | 769 (3 studies) | ⊕⊕⊕⊝ moderate4 | |
| Withdrawal due to adverse events | 24 per 10001 | 14 per 1000 (6 to 35) | RR 0.58 (0.23 to 1.44) | 940 (4 studies) | ⊕⊕⊝⊝ low5 | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Relative risk | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Control group risk estimates come from control arm of meta‐analysis, based on included trials. 2 Downgraded one level due to sparse data (153 events). 3 Downgraded two levels due to very sparse data (26 events). 4 Downgraded one level due to sparse data (271 events). 5 Downgraded two levels due to very sparse data (9 events).