Comparison 2. 5‐ASA versus sulfasalazine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to Induce Global/Clinical Remission	8	526	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.77, 1.04]
1.1 5‐ASA / SASP <1/2	1	29	Risk Ratio (M‐H, Fixed, 95% CI)	0.9 [0.57, 1.41]
1.2 1/1 > 5‐ASA / SASP >or= 1/2	5	359	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.77, 1.08]
1.3 5‐ASA / SASP >or= 1/1	3	138	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.59, 1.23]
2 Failure to Induce Global/Clinical Remission or Improvement	14	1053	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.76, 1.01]
2.1 5‐ASA / SASP <1/2	3	123	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.47, 1.27]
2.2 1/1 > 5‐ASA / SASP >or= 1/2	11	804	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.77, 1.05]
2.3 5‐ASA / SASP >or= 1/1	3	126	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.54, 1.22]
3 Failure to Induce Endoscopic Remission	2		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3.1 5‐ASA / SASP <1/2	0		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 1/1 > 5‐ASA / SASP >or= 1/2	2		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 5‐ASA / SASP >or= 1/1	0		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Failure to Induce Endoscopic Remission or Improvement	6	362	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.65, 1.02]
4.1 5‐ASA / SASP <1/2	1	29	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.58, 1.04]
4.2 1/1 > 5‐ASA / SASP >or= 1/2	4	246	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.53, 1.02]
4.3 5‐ASA / SASP >or= 1/1	2	87	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.72, 1.57]
5 Development of Any Adverse Event	12	909	Risk Ratio (M‐H, Fixed, 95% CI)	0.48 [0.36, 0.63]
5.1 5‐ASA / SASP <1/2	1	56	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.10, 1.20]
5.2 1/1 > 5‐ASA / SASP >or= 1/2	9	746	Risk Ratio (M‐H, Fixed, 95% CI)	0.55 [0.41, 0.73]
5.3 5‐ASA / SASP >or= 1/1	2	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.05, 0.52]
6 Withdrawal from Study due to Adverse Event	10	640	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.24, 0.68]
6.1 5‐ASA / SASP <1/2	2	85	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.02, 1.41]
6.2 1/1 > 5‐ASA / SASP >or= 1/2	5	361	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.32, 1.39]
6.3 5‐ASA / SASP >or= 1/1	4	194	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.10, 0.60]
7 Exclusions and Withdrawals after Entry	10	701	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.58, 0.99]
7.1 5‐ASA / SASP <1/2	1	29	Risk Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 1.80]
7.2 1/1 > 5‐ASA / SASP >or= 1/2	6	478	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.71, 1.34]
7.3 5‐ASA / SASP >or= 1/1	4	194	Risk Ratio (M‐H, Fixed, 95% CI)	0.44 [0.25, 0.77]