Study	Reason for exclusion
Adrizzone 2006	Trial does not have a placebo, SASP or other formulation of 5‐ASA comparison group. Trial compares 5‐ASA versus azathioprine
Ahluwalia 1992	Dose‐ranging study. The study does not provide details on pre‐specified outcomes
Gross 2011	Trial does not have a placebo, SASP or other formulation of 5‐ASA comparison group. Trial compared once daily dosing of mesalazine (Salofalk) with once daily budesonide
Irvine 2008	Pooled quality of life data from two RCTs (ASCEND I and ASCEND II)
Kamm 2009	Not a RCT ‐ open‐label extension study
Mahmood 2005	Oral 5‐ASA combined with trefoil factor 3 enema versus oral 5‐ASA combined with placebo enema
Paoluzi 2002	Trial looks at 4 weeks of combined oral and topical 5‐ASA (mesalazine) versus 8 weeks of combined oral and topical 5‐ASA (mesalazine)
Pruitt 1991	Single‐centre report abstracted from a larger multicenter trial (Sninsky 1991)
Safdi 1997	Trial compared oral mesalamine (Asacol) to mesalamine enema (Rowasa) to combination of oral mesalamine and enema
Vecchi 2001	Trial compared oral 5‐ASA (Salofalk) + placebo enema to oral 5‐ASA + 5‐ASA enema (Salofalk)
Vernia 2000	Trial compared oral mesalazine to combination of oral mesalazine + oral sodium butyrate