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. 1999 Jan 25;1999(1):CD001361. doi: 10.1002/14651858.CD001361

Comparison 3. HALOPERIDOL DECANOATE vs OTHER DEPOT ANTIPSYCHOTICS.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 2 97 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.15 [0.01, 2.37]
2 Global impression: 1. Needing additional antipsychotic treatment 2 113 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.63 [0.17, 2.30]
3 Global impression: 2. Clinical Global Impression (endpoint score, high=poor) 2 128 Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.22, 0.36]
4 Global impression: 3. Clinical Global Impression (skewed data, high=poor).     Other data No numeric data
5 Mental state: 1. Relapse 7 317 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.25 [0.65, 2.42]
6 Mental state: 2. BPRS (endpoint score, high=poor) 2 113 Mean Difference (IV, Fixed, 95% CI) 0.87 [‐0.97, 2.72]
7 Mental state: 3. Various scales (skewed endpoint data)     Other data No numeric data
7.1 general (BPRS, high = poor)     Other data No numeric data
7.2 general (CPRS, high = poor)     Other data No numeric data
7.3 general (Krawiecka scale, high = poor)     Other data No numeric data
7.4 specific ‐ depression     Other data No numeric data
8 Behaviour: 1. Leaving the study early 8 371 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.91 [0.52, 1.60]
9 Behaviour: 2. Wing Ward Behaviour Scale (skewed endpoint data, high=poor).     Other data No numeric data
10 Side effects: 1. Movement disorders 6   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
10.1 dyskinesia 2 105 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.27 [0.53, 3.06]
10.2 needing anticholinergic drugs 5 257 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.80 [0.43, 1.47]
10.3 tremor 1 41 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.76 [0.22, 2.59]
11 Side effects: 2. Movement disorders ‐ various scales (skewed endpoint data)     Other data No numeric data
11.1 parkinsonism (Simpson & Angus scale, high = poor)     Other data No numeric data
11.2 tardive dyskinesia (AIMS, high = poor)     Other data No numeric data
12 Side effects: 3. Significant side effects reported 1 64 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.70 [0.26, 1.86]