Chouinard 1984.
Methods | Allocation: randomised, stratified by sex & past frequency of depot administration. Blindness: double. Duration: 8 months. Statistics: last observation carried forward. | |
Participants | Diagnosis: schizophrenia (DSM III). History: on depot >3 months, duration ill ‐ mean 16 yrs, range 3‐38, informed consent given. N=72. Age: mean 44 yrs, range 18‐66. Sex: 36 M, 36 F. Setting: community. | |
Interventions | 1. Haloperidol decanoate: dose mean 225mg/injection, 2‐4 weekly, range 15‐900mg/injection. N=36. 2. Fluphenazine decanoate: dose mean 75mg/injection, 2‐4 weekly, range 2.5‐300mg/injection. N=36. | |
Outcomes | Global Impression (CGI).
Mental state (BPRS).
Leaving the study early.
Additional medication. Unable to use ‐ Side effects (ESRS ‐ authors own scale*, TESF ‐ no data reported). Physiological measures (prolactin, drug plasma levels ‐ non clinical outcomes, data not usable). |
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Notes | * Marshall et al, 1998. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |