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. 1999 Jan 25;1999(1):CD001361. doi: 10.1002/14651858.CD001361

Eklund 1991.

Methods Allocation: randomised. 
 Blindness: double. 
 Duration: 48 weeks (preceded by 15 week single blind 60mg HD/ month).
Participants Diagnosis: schizophrenia (RDC). 
 N=56 
 Age: mean ˜ 52 yrs (SD ˜ 12), range 25‐65. 
 Sex: 37 F, 19 M. 
 Setting: 37 community, 19 hospital.
Interventions 1. Haloperidol decanoate: dose mean 60mg/ injection (fixed dose regimen), every 4 weeks. N=18/N=20* 
 2. Placebo: N=23
Outcomes Leaving the study early.
Unable to use ‐ 
 Additional medication (>30% attrition) 
 Relapse (>30% attrition). 
 Side effects (EPSS ‐ >30% attrition). 
 Mental state (CPRS ‐ no SD). 
 Physiological measures (plasma levels).
Notes * N in HD group in abstract differs from N in paper. 
 Authors contacted ‐ no reply.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear