McKane 1987.
Methods | Allocation: randomised. Blindness: double. Duration: 60 weeks (preceded by 12 week 'run in' period where additional medication allowed). | |
Participants | Diagnosis: schizophrenia (Fiegner criteria*). History: on antipsychotics, duration ill ‐ mean 31 yrs, range 10‐50, next of kin gave consent. N=38. Age: mean 56 yrs, range 31‐ 71. Sex : 22 M, 16 F. Setting: in hospital. | |
Interventions | 1. Haloperidol decanaote: initial dose mean 127 mg/injection, week 12 dose mean 120mg/ injection, monthly. N=17. 2. Fluphenazine decanoate: initial mean dose 106mg/ injection, week 12 dose mean 105/ injection, monthly. N=16. | |
Outcomes | Mental state (Krawiecka scale).
Leaving the study early.
Additional medication.
Side effects (AIMS).
Parkinsonism (Simpson & Angus).
Behaviour (Wing Ward Behaviour Scale). Unable to use ‐ Global impresson (Global 5‐point scale ‐ no data). Physiological measures (prolactin, drug plasma levels ‐ non clinical outcomes, data not usable). |
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Notes | * Fiegner 1972 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |