Zissis 1982.

Methods	Allocation: randomised ‐ predetermined code. Blindness: double. Duration: 16 weeks.
Participants	Diagnosis: schizophrenia (Feighner criteria). History: on antipsychotics >2yrs, informed consent given, duration hospitalized ˜ 14 yrs. N=32. Age: mean ˜ 46 yrs (range 28‐ 60). Sex: 12 F, 4 M. Setting: in hospital.
Interventions	1. Haloperidol decanoate: dose mean 150mg/IM/month, initially, range 0.5‐1.5ml/IM, dose adapted to side effects. N=16. 2. Placebo IM. N=16. Haloperidol given orally if individual deteriorated.
Outcomes	Mental state: withdrawn due to lack of effect. Additional medication. Unable to use ‐ Global Impression (CGI ‐ no data reported)*. Mental state (BPRS ‐ no SD)**. Behaviour (NOSIE ‐ no SD)**.
Notes	Abstract & paper differed on numbers withdrawn ‐ used data in body of paper. >30% withdrawn due to lack of effect but all followed up. * reported to be not different between groups. ** reported as statistically different. Authors contacted ‐ no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear