Krupitsky 2006.

Methods	randomised controlled trial double blind, double dummy
Participants	280 patients with primary diagnosis of opioid dependence according to DSM IV , abstinence from heroin and other substance of abuse , including alcohol for at last one week, at least one relative who was willning to participate in treatment. Mean age 23.6 years, male: 72.25%
Interventions	group A: naltrexone 50 mg/day + fluoxeitine 20 mg/day + drug counselling (n. 70) group B: naltrexone 50 mg/day + fluoxeitine placebo + drug counselling(n. 70) group C: naltrexone placebo+ fluoxeitine 20 mg/day + drug counselling(n. 70) group D: naltrexone placebo + fluoxeitine placebo + drug counselling(n. 70) Study duration : 6 months
Outcomes	retention and no relapsing use of alcohol and other substance of abuse craving side effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	method of sequence generation not reported
Allocation concealment?	Unclear risk	method for allocation concealment not reported
Blinding? objective outcomes	Low risk	double blind, double dummy
Blinding? subjective outcomes	Low risk	double blind, double dummy
Incomplete outcome data addressed? All outcomes	High risk	outcomes other than retention and relapsing measured only on patients who remained in treatment