| Methods |
randomised, controlled trial
not blind |
| Participants |
20 detoxified opioid addicts male and female; age range: 20‐35 years; opioid free for at least 10 days; |
| Interventions |
naltrexone plus psychotherapy (15) versus psychotherapy alone (5); outpatients.
naltrexone: induction: 50 mg/day for three weeks; then Monday 100 mg, Wednesday 100 mg, Friday 150 mg.
Psychotherapy: daily group therapy plus weekly individual therapy
study duration: information not reported (duration of treatment of patients: min 34 max 124 days) |
| Outcomes |
use of substance af abuse measured by urine analysis
adverse effects |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
information not reported |
| Allocation concealment? |
Unclear risk |
information not reported |
| Blinding?
objective outcomes |
Low risk |
open label trial, but the outcomes are unlikely to be influenced by lack of blinding |
| Blinding?
subjective outcomes |
High risk |
open label |
| Incomplete outcome data addressed?
All outcomes |
High risk |
results reported for 14 of 15 patients in the intervention group and for 3 of 5 in the control group.. Information not given on the patients lost |
