| Methods |
randomised placebo controlled trial
double‐blind |
| Participants |
32 male Israeli heroin addicts after detoxification abstinent for at least 10 days; mean age:32 years; 72% marries, 84 did not complete the secondary education, 50% involved in criminal activity |
| Interventions |
behavioral and supportive psychotherapy plus naltrexone (16) vs. behavioral and supportive psychotherapy plus placebo (16)
50 mg/week for the first two weeks at the visit to the clinic; 50 mg at the visit to the clinic plus two more tablets to take at home during the weekend (total 150 mg/week) for the following weeks
Outpatients setting
study duration: 12 weeks |
| Outcomes |
retention in treatment
use of primary substance: patient drug free at the end of treatment
adverse effects |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
method of sequence generation not reported |
| Allocation concealment? |
Unclear risk |
method for allocation concealment not reported |
| Blinding?
objective outcomes |
Low risk |
double blind |
| Blinding?
subjective outcomes |
Low risk |
double blind |
| Incomplete outcome data addressed?
All outcomes |
Low risk |
number of subjects who dropped out and reason reported for each group |
