Stella 2005.

Methods	randomised controlled trial
Participants	56 patients with a diagnosis of opioid dependence according to DSM IV . Compltete detoxification obtained by methadone or symptomatic therapy . Mean age not reported, 51 males.
Interventions	group A: naltrexone 50 mg/day plus psychosocial support(n.14) Group B: naltrexone 50 mg/day plus placebo plus psychosocial support(n.14) Group C: naltrexone 50 mg/day plus prazepam plus psychosocial support(n.14) Group D: psychosocial support(n.14) Duration of trial: 6 months
Outcomes	patient opiate free at the end of trial patients with positive urine for other substance of abuse side effects insomnia, panic attack, hyperexcitability
Notes	only groups B and C were double blind
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	method of sequence generation not reported
Allocation concealment?	Unclear risk	method for allocation concealment not reported
Blinding? objective outcomes	Low risk	only groups comparing prazepam versus placebo were double blind. Comment: the outcomes are unlikely to be biased by lack of blnding
Blinding? subjective outcomes	High risk	only groups comparing prazepam versus placebo were double blind.
Incomplete outcome data addressed? All outcomes	Low risk	no drop out form the study