Study	Reason for exclusion
Altman 1976	Excluded as the study design and the outcomes were not in the inclusion criteria of the review: cross‐over study and heroin self‐administration
Anton 1981	Excluded as the study design was not in the inclusion criteria of the review: participants selected retrospectively, there is not a control group, all received naltrexone
Arndt 1984	Excluded as the study design was not in the inclusion criteria of the review: participants selected retrospectively.
Brahen 1977	Excluded as the study design was not in the inclusion criteria of the review: cross‐over study
Brahen 1978	Excluded as the study design was not in the inclusion criteria of the review:not controlled study
Callahan 1980	Excluded as the type of intervention was not in the inclusion criteria of the review: all participants received naltrexone
Crowley 1985	Excluded as the study design was not in the inclusion criteria of the review: cross‐over study
Gerra 1995	Excluded as the type of intervention was not in the inclusion criteria of the review: in the experimental interventions group participants received naltrexone plus clonidine
Greenstein 1984	Excluded as the study design was not in the inclusion criteria of the review: not randomised controlled study
Grey 1986	Excluded as the study design was not in the inclusion criteria of the review: observational study
Hollister 1977	Excluded as the study design was not in the inclusion criteria of the review: not randomised controlled study
Hurzeler 1976	Excluded as the study design was not in the inclusion criteria of the review: not randomised controlled study
Judson 1981	Excluded as the type of intervention was not in the inclusion criteria of the review: all participants received naltrexone
Judson 1983	Excluded as the type of intervention was not in the inclusion criteria: LAAM treatment, introduction onto naltrexone
Judson 1984	Excluded as the type of intervention was not in the inclusion criteria of the review: LAAM treatment
Lewis 1978	Excluded as the study design was not in the inclusion criteria of the review: not randomised controlled study
Martin 1973	Excluded as the study design was not in the inclusion criteria of the review: cross‐over study
Mello 1981	Excluded because it is not possible to extract the data about any outcome considered in the review.
Navaratnam 1994	Excluded as the type of intervention was not in the inclusion criteria of the review: naltrexone as a basic treatment in a study performed on other pharmacological effects
Nunes 2006	Excluded as the type of intervention was not in the inclusion criteria of the review: behavioral intervention to enhance compliance with naltrexone
O`Brien 1975	Excluded as the type of intervention was not in the inclusion criteria of review: naltrexone as a basic treatment in a study performed on other pharmacological effects
Osborn 1986	Excluded as the study design was not in the inclusion criteria of the review: observational study (same data of Grey 1986)
Raby 2009	Excluded because the type of outcome was not in the inclusion criteria of the review: cannabis use as a factor enhancing adherence to naltrexone treatment
Rea 2004	Excluded as the type of intervention was not in the inclusion criteria of the review: no control group, naltrexone at different doses
Resnick 1974	Excluded as the study design was not in the inclusion criteria of the review: not controlled study
Rothenberg 2002	Excluded as the study design was not in the inclusion criteria of the review: not controlled study
Sideroff 1978	Excluded as the study design was not in the inclusion criteria of the review: not controlled study
Taintor 1975	Excluded as the study design was not in the inclusion criteria of the review: not controlled study
Tennant 1984	Excluded as the study design was not in the inclusion criteria of the review: not controlled study
Volavka 1976	Excluded as the type of intervention was not in the inclusion criteria of the review: naltrexone as a basic treatment in a study performed on other pharmacological effects