Rith‐Najarian 1998.

Methods	ITS Intervention independent of other changes: DONE Sufficient data points to enable reliable statistical inference: NOT DONE Formal test of trend: N/A Intervention unlikely to affect data collection: DONE Blinded assessment: DONE Completeness of data set: DONE Reliable outcomes: NOT CLEAR
Participants	Rural primary care clinic in northern Minnesota (US). A foot‐care team was formed consisting of a family physician, two clinic nurses, a home care nurse, a nutritionist and a registrar. Patients were American Indians identified through surveillance having diabetes. They were entered into a diabetes registry and followed thereafter (not clear which type of diabetes). Provider ‐ 1 physician + 3 nurses (+nutritionist+registrar) patients ‐ 449 practices ‐ 1
Interventions	Intervention group: Professional intervention (distribution of educational materials + reminders) + organisational intervention (clinical multidisciplinary team) Control group: N/A Length of intervention: 3 years
Outcomes	PROCESS: NONE PATIENT: Lower‐extremity amputation (LEA) First LEA Major LEA (defined as either a "below the knee amputation" or an "above the knee amputation")
Notes	Local guidelines ‐directed at diagnosis, treatment, monitoring and risk factor assessment ‐targets: to reduce lower‐extremity amputations
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	D ‐ Not used