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. 2020 Feb 20;11:65. doi: 10.3389/fphar.2020.00065

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Copyright © 2020 Fu, Zhang, Zeng, Tian, Jin, Wang, Xu, Chen, Zheng and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of QNDP on the expression of NLRP3, ASC, and cleaved caspase 1 following OGD in SH-SY5Y cells. (A) Western blotting bands of NLRP3, ASC, C-caspase 1, pro-caspase 1, (B) Cell survival rate using CCK-8 assay. Western blotting analysis of NLRP3 (C), ASC (D), C-caspase 1/pro-caspase 1 (E). (F) Immunocytochemical staining for NLRP3 (red), the nuclei were stained blue with DAPI. Scale bar indicates 10 μm. Data are presented as the mean ± SEM, n = 3-5 batches of cells, **p < 0.01 compared with the sham group, ^# p < 0.05, ^## p < 0.01 compared with the MCAO group.