Table 2. Isolation date, sampling site, and resistance genes of carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates, Singapore, 2013–2015.
| Isolate | Patient no. | Date of isolation | Sampling site | β-lactam resistance genes | Other resistance genes |
|---|---|---|---|---|---|
| ENT494 | A2 | 2013 Jun 7 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT646 | A2 | 2013 Sep 18 | Blood | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A), qnrB1, aac(6')-lb-cr, catB3, dfrA14 |
| ENT1734 | A2 | 2014 Dec 19 | Rectum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A), catB3, aac(6')-lb-cr |
| ENT1061 | A4 | 2014 Mar 13 | Blood | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1256 | A6 | 2014 Jun 20 | Rectum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1332 | A8 | 2014 Jul 13 | Rectum | blaSHV-1, blaKPC-2, blaTEM-1A, blaTEM-1B, blaCTX-M-15 | oqxA, oqxB, fosA6, mph(A), aac(6')-lb-cr, aadA16, qnrB6, arr-3, sul1, tet(A), dfrA27 |
| ENT1381 | A12 | 2014 Aug 10 | Midstream urine | blaSHV-75, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A) |
| ENT1192 | A14 | 2014 May 24 | Rectum | blaSHV-1, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA5, mph(A), aac(6')-lb-cr, qnrB1, catB3, tet(A), dfrA14 |
| ENT1988 | A14 | 2015 Apr 16 | Feces, rectum | blaSHV-1, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA5, mph(A), aac(6')-lb-cr, qnrB1, catB3, tet(A), dfrA14 |
| ENT596 | A15 | 2013 Aug 22 | Urine | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT607 | A15 | 2013 Aug 22 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A), aadA1, cmlA1, arr-2, sul1 |
| ENT686 | A15 | 2013 Oct 4 | Tracheostomy aspirate | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | fosA6, mph(A) |
| ENT715 | A15 | 2013 Oct 17 | Trachea aspirate | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT750 | A15 | 2013 Oct 31 | Blood | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT758 | A15 | 2013 Oct 31 | Tracheal aspirate | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT883 | A15 | 2013 Dec 14 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1072 | A15 | 2014 Mar 26 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1077 | A15 | 2014 Mar 28 | Rectum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A), tet(A), dfrA14 |
| ENT495* | 2013 Jun 8 | Not known | blaOKP-B-6, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A), tet(A), dfrA14, aac(6')-Ib-cr, aadA1, arr-2, cmlA5, ereA, qnrB1, sul1 | |
| SGH10 | Not applicable | Blood | bla SHV-11 | oqxA, oqxB, fosA6 |
*Control carbapenem-resistant K. pneumoniae isolate (classified as K. quasipneumoniae by GenBank).