Table 2.

Univariable Cox regression models for the association of selected factors with TCZ discontinuation rate.

Parameter	Category vs. reference	npt	nevents	HR	(95%CI)	p-value
Age (years)	18–60 vs >60	104 vs 79	7 vs 10	0.52	(0.20–1.35)	0.179
Gender	males vs females	22 vs 161	0 vs 17	0.20	(0.01–3.59)	0.275a,b
BMI (kg/m2)	<25 vs ≥25	56 vs 127	6 vs 11	1.25	(0.46–3.39)	0.657
RF/anti-CCP status	RF(−) and anti-CCP(−) vs RF(+) and/or anti-CCP(+)	34 vs 130	3 vs 13	0.89	(0.25–3.14)	0.861
Type of TCZ therapy	TCZ monotherapy vs TCZ combination therapy	30 vs 153	4 vs 13	1.60	(0.52–4.90)	0.412
Prior bDMARD therapy	0–1 vs ≥2	116 vs 67	8 vs 9	0.50	(0.19–1.29)	0.152

^aFirth’s correction was used due to zero events in male patients.

^bProportional hazards assumption was violated.

CI: confidence interval; HR: hazard ratio.