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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Biomaterials. 2019 Dec 30;233:119750. doi: 10.1016/j.biomaterials.2019.119750

Fig. 6. Attenuation of pulmonary hypertension-induced alterations in expression of genes implicated in PAH pathogenesis by combinational feeding with bioencapsulated CTB-ACE2 and CTB-Ang-(1–7).

Fig. 6.

(A) MAS1, (B) AGTR1, (C) IL-1β, (D) IL1R1, and (E) TGF-β1 mRNA levels were determined by real time RT-PCR and are expressed as fold change Ct vs. peptidylprolyl isomerase A (Ppia) expression levels. CTB-ACE2, CTB-Ang-(1–7) or PBS were administered as outlined in Figure 4. Each data point represents one animal. Values are means ± SEM. #p <0.05 vs. control, *p <0.05 vs. sham by one-way ANOVA and post-hoc Newman-Keuls test. Ctrl = untreated control; MCT = monocrotaline.