Table 2:

Median values of cytokines and cytokine receptors in the 1^st and 2^nd visit before and after the treatment with celecoxib and etoricoxib in the respective group and in the control group. Values are in pg/ml

	Celecoxib group			Etoricoxib group			Control group
	1st visit Median (IQR)	2nd visit Median (IQR)	p	1st visit Median (IQR)	2nd visit Median (IQR)	p	1st visit Median (IQR)	2nd visit Median (IQR)	p
IL1β S	0.24 (0.56)	0.15 (0.12)	NS	0.45 (0.51)	0.23 (0.18)	0.045	0.19 (0.19)	0.21 (0.31)	NS
IL1β JF	0.65 (0.92)	0.20 (0.62)	NS	2.30 (5.77)	1.60 (5.85)	NS	0.40 (0.43)	0.54 (0.88)	0.001
IL1Ra S	240.0 (180.0)	250.0 (110.0)	NS	250.0 (195.0)	230.0 (295.0)	NS	460.0 (740.0)	710.0 (940.0)	NS
IL1Ra JF	340.0 (2210.0)	460.0 (5000.0)	<0.001	460.0 (8210.0)	1100.0 (8600.0)	NS	450.0 (1475.0)	400.0 (1095.0)	NS
IL6 S	1.30 (2.34)	1.20 (1.67)	0.003	1.70 (9.38)	1.35 (9.55)	NS	1.65 (1.10)	1.60 (1.80)	NS
IL6 JF	500.0 (5010.0)	420.0 (2065.0)	0.017	1450.0 (11360.0)	880.0 (3140.0)	0.019	300.0 (1300.0)	300.0 (1340.0)	NS
TNF-α S	1.20 (0.60)	1.10 (0.40)	NS	1.70 (1.00)	1.10 (1.40)	NS	1.30 (0.40)	1.30 (0.35)	NS
TNF-α JF	1.50 (2.89)	1.00 (3.10)	NS	2.90 (5.15)	1.40 (3.70)	NS	1.10 (1.25)	1.70 (2.80)	0.01
sTNFR1 S	1650.0 (500.0)	1450.0 (450.0)	NS	2000.0 (1200.0)	1650.0 (1350.0)	NS	1550.0 (1300.0)	1450.0 (750.0)	NS
sTNFR1 JF	5000.0 (4500.0)	7200.0 (4000.0)	NS	7200.0 (5600.0)	8400.0 (4600.0)	NS	7200.0 (7300.0)	5600.0 (6300.0)	NS
sTNFR2 S	3000.0 (600.0)	2800.0 (500.0)	NS	3300.0 (1000.0)	2800.0 (600.0)	NS	3400.0 (2800.0)	3300.0 (2950.0)	NS
sTNFR2 JF	3500.0 (4400.0)	4250.0 (3400.0)	NS	4200.0 (5800.0)	5750.0 (9000.0)	0.017	4800.0 (5450.0)	3600.0 (4200.0)	NS

NS: non significant, IQR: interquartile range, s: soluble, S: serum, JF: joint fluid