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. Author manuscript; available in PMC: 2020 Feb 27.
Published in final edited form as: Endocr Relat Cancer. 2019 Jun;26(6):R345–R368. doi: 10.1530/ERC-18-0309

Figure 2.

Figure 2

Differential dependency network focused on the KEGG apoptosis pathway (Kanehisa & Goto 2000). Recurrent breast cancers (uniquely featured by red edges) showed the imbalance between apoptosis and survival with only one route into the cell through IL1B-induced inhibition of proapoptotic CASP3. Non-recurrent breast cancer (uniquely featured by green edges) had a cascade of signaling pathways inside the cell that provides the balance between apoptosis and survival. Copyright Kanehisa Laboratories. Reproduced with permission from KEGG.