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. Author manuscript; available in PMC: 2020 Feb 27.
Published in final edited form as: Endocr Relat Cancer. 2019 Jun;26(6):R345–R368. doi: 10.1530/ERC-18-0309

Figure 3.

Figure 3

(A) The estrogen-response landscape for a particular level of estrogen stimulation. There are four basins of attraction for the cell state corresponding to sensitive (ERM−/GFR−), hypersensitive (ERM+/GFR−) and independent (GFR+). (B) A sample intermittent treatment regimen (top panel) produces varying proportion of cells in different states (second panel; cyan = sensitive, green = hypersensitive, blue = independent), a varying proliferation index of the overall cell population (third panel; yellow indicates death and red indicates growth). The overall population level, starting from 1000 cells, is shown in the bottom panel. (C) Plot of the average value of cell number <log10 N> over the interval t ϵ (2 × 104, 3 × 104) as a function of Ttreat and Tbreak. The white dot indicates the case in (B). Any combination of Ttreat and Tbreak that puts the system within the log10N = 3 contour will suppress cancer growth. This figure is adapted, with permission, from Fig. 3 and 6 of Chen et al. (2014).