Comparison 1. Cotrimoxazole versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	1	534	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.53, 0.85]
2 Adverse events	1	534	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.47, 1.73]
3 Hospital admission	1	534	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.62, 0.96]
4 Death by age	1	534	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.52, 0.84]
4.1 age<2	1	190	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.45, 0.88]
4.2 age >2	1	344	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.50, 0.97]
5 Death by CD4%	1	393	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.46, 0.84]
5.1 <15%	1	272	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.44, 0.85]
5.2 >15%	1	121	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.30, 1.47]