Table 1.
Baseline Characteristics of Patients With AD and Matched Unexposed Patients
| AD Patients (n = 1580) | Matched Unexposed Patients (n = 3158) | |
|---|---|---|
| Age years, mean ± SD | 51.7 ± 18.5 | 51.7 ± 18.5 |
| Male sex, n (%) | 666 (42.2) | 1.330 (42.1) |
| BMI, total N | 1227 | 2264 |
| median (interquartile range) | 24.3 (21.5–27.6)a | 25.5 (22.6–28.9) |
| ˂18.5 kg/m2, n (%) | 87 (7.1) | 51 (2.3) |
| 18.5–25 kg/m2, n (%) | 606 (49.4) | 973 (43.0) |
| 25–30 kg/m2, n (%) | 362 (29.5) | 791 (34.9) |
| ≥30 kg/m2, n (%) | 172 (14.0) | 449 (19.8) |
| Missing, n | 353 | 894 |
| Smoking status, total N | 1384 | 2679 |
| Nonsmoker, n (%) | 882 (63.7)a | 1548 (57.8) |
| Ex-smoker, n (%) | 250 (18.1) | 490 (18.3) |
| Smoker, n (%) | 252 (18.2)a | 641 (23.9) |
| Missing, n | 196 | 479 |
| Townsend Deprivation Index, total N | 1373 | 2780 |
| 1 (least deprived), n (%) | 350 (25.5) | 743 (26.7) |
| 2, n (%) | 306 (22.3) | 590 (21.2) |
| 3, n (%) | 290 (21.1) | 607 (21.8) |
| 4, n (%) | 255 (18.6) | 471 (16.9) |
| 5 (most deprived), n (%) | 172 (12.5) | 369 (13.3) |
| Missing, n | 207 | 378 |
| Charlson Comorbidity Index | ||
| 0 (no comorbidities), n (%) | 863 (54.6)a | 2263 (71.7) |
| 1, n (%) | 377 (23.9)a | 536 (17.0) |
| ≥2 (more comorbidities), n (%) | 340 (21.5)a | 359 (11.4) |
| Associated autoimmune comorbidities | ||
| Hyperthyroidism, n (%) | 40 (2.5)a | 16 (0.5) |
| Hypothyroidism, n (%) | 457 (28.9)a | 122 (3.9) |
| Rheumatoid arthritis, n (%) | 25 (1.6) | 37 (1.2) |
| Type 1 diabetes mellitus, n (%) | 127 (8.0)a | 15 (0.5) |
| Inflammatory bowel disease, n (%) | 29 (1.8)a | 22 (0.7) |
| Crohn’s disease, n (%) | 9 (0.6) | 9 (0.3) |
| Ulcerative colitis, n (%) | 20 (1.3)a | 11 (0.4) |
| Coeliac disease, n (%) | 25 (1.6)a | 10 (0.3) |
| Multiple sclerosis, n (%) | <5 | 8 (0.3) |
| Pernicious anaemia, n (%) | 41 (2.6)a | 15 (0.5) |
| Systemic lupus erythematosus, n (%) | 6 (0.4) | n < 5 |
a P < 0.05 for AD patients vs. unexposed cohort.