Table 2.
Baseline Characteristics of the CAH Patients and Matched Unexposed Patients
| CAH Cohort (n = 602) | Matched Unexposed Cohort (n = 1204) | CAH Cohort on Glucocorticoids (n = 254) | Matched Unexposed Cohort (n = 508) | CAH Cohort Not on Glucocorticoids (n = 348) | Matched Unexposed Cohort (n = 696) | |
|---|---|---|---|---|---|---|
| Age, years, mean ± SD | 35.4 ± 16.3 | 35.5 ± 16.2 | 33.4 ± 15.1 | 33.5 ± 15.0 | 36.9 ± 17.0b | 37.0 ± 16.9 |
| Male sex, n (%) | 167 (27.7) | 334 (27.7) | 80 (31.5) | 160 (31.5) | 87 (25.0) | 174 (25.0) |
| BMI, total N | 438 | 835 | 186 | 340 | 252 | 495 |
| Median (interquartile range) | 26.9 (23.2–31.2)a | 24.0 (21.0–28.0) | 27.0 (23.2–32.0)a | 24.0 (21.3–27.9) | 26.9 (23.2–30.9)a | 24.4 (21.8–28.3) |
| <18.5, n (%) | 12 (2.7) | 35 (4.2) | 8 (4.3) | 9 (2.6) | 4 (1.6) | 26 (5.2) |
| 18.5–25, n (%) | 162 (37.0) | 431 (51.6) | 68 (36.6) | 187 (55.0) | 94 (37.3) | 244 (49.3) |
| 25–30, n (%) | 133 (30.4) | 224 (26.8) | 52 (28.0) | 90 (26.5) | 81 (32.1) | 134 (27.1) |
| ≥30, n (%) | 131 (29.9) | 145 (17.4) | 58 (31.2) | 54 (15.9) | 73 (29.0) | 91 (18.4) |
| Missing, n | 164 | 369 | 68 | 168 | 96 | 201 |
| Smoking status, total N | 524 | 1048 | 212 | 423 | 312 | 625 |
| Non-smoker, n (%) | 349 (66.6) | 670 (63.9) | 138 (65.1) | 277 (65.5) | 211 (67.6) | 393 (62.9) |
| Ex-smoker, n (%) | 71 (13.6) | 142 (13.6) | 28 (13.2) | 50 (11.8) | 43 (13.8) | 92 (14.7) |
| Smoker, n (%) | 104 (19.9) | 236 (22.5) | 46 (21.7) | 96 (22.7) | 58 (18.6) | 140 (22.4) |
| Missing, n | 78 | 156 | 42 | 85 | 36 | 71 |
| Townsend Deprivation Index, total N | 516 | 1057 | 223 | 459 | 293 | 598 |
| 1 (least deprived), n (%) | 123 (23.8) | 235 (22.2) | 52 (23.3) | 107 (23.3) | 71 (24.2) | 128 (21.4) |
| 2, n (%) | 107 (20.7) | 222 (21.0) | 46 (20.6) | 92 (20.0) | 61 (20.8) | 130 (21.7) |
| 3, n (%) | 114 (22.1) | 232 (22.0) | 51 (22.9) | 99 (21.6) | 63 (21.5) | 133 (22.2) |
| 4, n (%) | 104 (20.2) | 225 (21.3) | 44 (19.7) | 98 (21.4) | 60 (20.5) | 127 (21.2) |
| 5 (most deprived), n (%) | 68 (13.2) | 143 (13.5) | 30 (13.5) | 63 (13.7) | 38 (13.0) | 80 (13.4) |
| Missing, n | 86 | 147 | 31 | 49 | 55 | 98 |
| Charlson Comorbidity Index | ||||||
| 0 (no comorbidities), n (%) | 457 (75.9) | 907 (75.3) | 187 (73.6) | 394 (77.6) | 270 (77.6) | 513 (73.7) |
| 1, n (%) | 103 (17.1) | 242 (20.1) | 50 (19.7) | 96 (18.9) | 53 (15.2) | 146 (21.0) |
| ≥2 (more comorbidities), n (%) | 42 (7.0) | 55 (4.6) | 17 (6.7) | 18 (3.5) | 25 (7.2) | 37 (5.3) |
a P < 0.05 for CAH patients vs. unexposed cohort.
b P < 0.05 for CAH patients on glucocorticoids vs. CAH patients not on glucocorticoids.