Table 3.
Absolute and relative risk of infections in AD patients and matched cohort
| AD Cohort (n = 1580) | Matched Unexposed Cohort (n = 3158) | |
|---|---|---|
| Lower respiratory tract infections | ||
| Outcome events, n (%) | 130 (8.2) | 137 (4.3) |
| Person-years, n | 10 337 | 22 836 |
| Crude incidence rate/1000-person years | 12.58 | 6.00 |
| Follow-up years, median (interquartile range) | 4.87 (1.78–10.20) | 5.78 (2.37–11.12) |
| Unadjusted incidence rate ratio (95% CI) | 2.10 (1.65–2.66) | |
| P-value | 0.001 | |
| Adjusted incidence rate ratio (95% CI)a | 2.11 (1.64–2.69) | |
| P-value | 0.001 | |
| Urinary tract infections | ||
| Outcome events, n (%) | 282 (17.9) | 396 (12.5) |
| Person-years, n | 9 248 | 21 003 |
| Crude incidence rate/1000-person years | 30.49 | 18.85 |
| Follow-up years, median (interquartile range) | 4.09 (1.44–9.14) | 5.08 (2.11–10.26) |
| Unadjusted incidence rate ratio (95% CI) | 1.62 (1.39–1.88) | |
| P-value | 0.001 | |
| Adjusted incidence rate ratio (95% CI)a | 1.51 (1.29–1.77) | |
| P-value | 0.001 | |
| Gastro-intestinal infections | ||
| Outcome events, n (%) | 194 (12.3) | 110 (3.5) |
| Person-years, n | 9 598 | 22 662 |
| Crude incidence rate/1000-person years | 20.21 | 4.85 |
| Follow-up years, median (interquartile range) | 4.49 (1.67–9.31) | 5.63 (2.37–11.03) |
| Unadjusted incidence rate ratio (95% CI) | 4.16 (3.30–5.26) | |
| P-value | 0.001 | |
| Adjusted incidence rate ratio (95% CI)a | 3.80 (2.99–4.84) | |
| P-value | 0.001 |
aAdjusted for age, gender, smoking status, BMI, Townsend Deprivation Index and Charlson Comorbidity Index.