Table 6.
Antimicrobial Prescription Counts in CAH Patients Compared to the Matched control Cohort
| CAH Cohort (n = 602) | Matched Unexposed Cohort (n = 1204) | CAH Cohort on Glucocorticoids (n = 254) | Matched Unexposed Cohort (n = 508) | CAH Cohort Not on Glucocorticoids (n = 348) | Matched Unexposed Cohort (n = 696) | |
|---|---|---|---|---|---|---|
| Antibiotics prescriptions | ||||||
| Count of prescriptions, n | 3543 | 4930 | 2134 | 2088 | 1409 | 2842 |
| Person-years, n | 3941 | 7957 | 1974 | 3611 | 1967 | 4346 |
| Count rates (per 1000 years) | 899 | 619 | 1081 | 578 | 716 | 654 |
| Follow-up years, median (interquartile range) | 4.85 (1.95–10.32) | 5.23 (2.09–9.90) | 6.12 (2.67–12.48) | 5.32 (2.54–10.87) | 4.12 (1.54–8.30) | 5.20 (1.88–9.62) |
| Unadjusted incidence rate ratio (95% CI) | 1.45 (1.39–1.51) | 1.87 (1.76–1.99) | 1.10 (1.03–1.17) | |||
| P-value | 0.001 | 0.001 | 0.01 | |||
| Adjusted incidence rate ratio (95% CI)a | 1.46 (1.39–1.52) | 1.77 (1.66–1.89) | 1.15 (1.08–1.23) | |||
| P-value | 0.001 | 0.001 | 0.001 | |||
| Antifungals prescriptions | ||||||
| Count of prescriptions, n | 302 | 330 | 159 | 130 | 143 | 200 |
| Person-years, n | 3941 | 7957 | 1974 | 3611 | 1967 | 4346 |
| Count rates (per 1000 years) | 77 | 41 | 81 | 36 | 73 | 46 |
| Follow-up years, median (interquartile range) | 4.85 (1.95–10.32) | 5.23 (2.09–9.90) | 6.12 (2.67–12.48) | 5.32 (2.54–10.87) | 4.12 (1.54–8.30) | 5.20 (1.88–9.62) |
| Unadjusted incidence rate ratio (95% CI) | 1.85 (1.58–2.16) | 2.24 (1.77–2.82) | 1.58 (1.27–1.96) | |||
| P-value | 0.001 | 0.001 | 0.001 | |||
| Adjusted incidence rate ratio (95% CI)a | 1.69 (1.44–1.99) | 1.91 (1.50–2.43) | 1.47 (1.18–1.83) | |||
| P-value | 0.001 | 0.001 | 0.001 |
aAdjusted for age, gender, smoking status, BMI, Townsend Deprivation Index and Charlson Comorbidity Index.