Table 4.
Associations From Linear Regression Model Between First Trimester EDC PC and Maternal (first trimester or term) and Neonatal Oxidative Stress Biomarkers
| Oxidative Stress Markerb | ||
|---|---|---|
| PC Variablea | Positive Association | Negative Association |
| First trimester oxidative stress levels | ||
| PC 1 | NY | |
| PC 3 | CY | |
| PC 4 | CY | |
| PC 10 | CY | |
| PC 11 | NY, CY | |
| Term oxidative stress levels | ||
| PC 9 | CY | |
| PC 11 | DY | |
| Neonatal cord oxidative stress levels | ||
| PC 1 | NY | |
| PC 10 | CY | |
| Differences in oxidative stress levels between first trimester and term | ||
| PC 9 | CY | |
Only significant relationships under the BH FDR 0.1 control for multiple testing are shown.
Abbreviations: CY, 3-chlorotyrosine; DY, o, o′-dityrosine; EDC, endocrine disrupting chemical; NY, 3-nitrotyrosine; PC principal component.
aPCs were based on EDC exposures measured in first trimester.
bOxidative stress markers were measured at the timepoint listed.