Table 1.

Suggested criteria for the diagnosis of ‘ASIA’

Major Criteria: Exposure to an external stimuli (Infection, vaccine, silicone, adjuvant) prior to clinical manifestations. The appearance of ’typical’ clinical manifestations: - Myalgia, Myositis or muscle weakness - Arthralgia and/or arthritis - Chronic fatigue, un-refreshing sleep or sleep disturbances - Neurological manifestations (especially associated with demyelination) - Cognitive impairment, memory loss - Pyrexia, dry mouth Removal of inciting agent induces improvement Typical biopsy of involved organs

Minor Criteria: The appearance of autoantibodies or antibodies directed at the suspected adjuvant Other clinical manifestations (i.e. irritable bowel syn.) Specific HLA (i.e. HLA DRB1, HLA DQB1) Evolvement of an autoimmune disease (i.e. MS, SSc)