Table 4:

Associations between mouse allergen reduction and FEF_25–75 growth^*

Lung function index	Achieved reduction ↑in mL(95%CI)	Did not achieve reduction ↑in mL(95%CI)	Difference in estimated FEF25–75% growth (95%CI)**	p-value of interaction term*** (reduction*time)
Reduction metric: ≥50% mean reduction from baseline
Pre-BD FEF25–75	174mL (95 – 253) n=153	55mL (−16 – 126) n=194	119mL (13 – 226)	p=0.03
Post-BD FEF25–75	251mL (165 – 337) n=152	113mL (35 – 190) n=192	138mL (23 – 254)	p=0.02
Reduction metric: ≥75% mean reduction from baseline
Pre-BD FEF25–75	245mL (140 – 351) n=90	63mL (2 – 123) n=257	182mL (61 – 304)	p=0.003
Post-BD FEF25–75	310mL (195 – 425) n=90	129mL (63 – 194) n=254	181mL (48 – 314)	p=0.008
Reduction metric: ≥90% mean reduction from baseline
Pre-BD FEF25–75	244mL (79 – 409) n=42	93mL (37 – 149) n=305	151mL (−23 – 325)	p=0.09
Post-BD FEF25–75	275mL (96 – 456) n=42	163mL (102 – 224) n=302	112mL (−78 – 302)	p=0.25

^*Average change over 1 year the mean participant (10yo black male)

^**Participants who achieved mean reduction minus participants who did not achieve mean reduction

^***Adjusted for age, sex, race, group assignment, BD reversibility, and atopy (number of positive SPT), n=291