—Comparison of COG categories from different Wolbachia supergroups. (A) PCA of Wolbachia genomes based on the proportion of annotated genes in each COG category. (B) PCA of Wolbachia genomes excluding X category genes. (C) Bar chart comparing COG categories between Wolbachia supergroups A and B. Abbreviations of COG categories are C, energy production and conversion; D, cell cycle control, cell division, and chromosome partitioning; E, amino acid transport and metabolism; F, nucleotide transport and metabolism; G, carbohydrate transport and metabolism; H, coenzyme transport and metabolism; I, lipid transport and metabolism; J, translation, ribosomal structure, and biogenesis; K, transcription; L, replication, recombination, and repair; M, cell wall/membrane/envelope biogenesis; N, cell motility; O, posttranslational modification, protein turnover, and chaperones; P, inorganic ion transport and metabolism; Q, secondary metabolites biosynthesis, transport, and catabolism; R, general function prediction only; S, function unknown; T, signal transduction mechanisms; U, intracellular trafficking, secretion, and vesicular transport; V, defense mechanisms; X, mobilome, prophages, and transposons.