. Author manuscript; available in PMC: 2020 Feb 27.

Published in final edited form as: Chemistry. 2018 Mar 27;24(23):6030–6035. doi: 10.1002/chem.201705771

Table 1.

Percent yield of monoadducts and crosslink adducts formed with DMC at 37°C. ND: non detected.

Oligonucleotide	9a	9b	R 9b/9a	10a	10b	Crosslinking efficiency	Total dG adducts
11 (GpC)	0.03^a	0.34 (±0.02)	11.4^b	ND	0.22 (±0.03)	39%	0.57(±0.02)
12 (GpC)	0.14 (±0.007)	0.55 (±0.005)	7.1 (±0.8)	ND	0.12 (±0.02)	18%	0.82(±0.005)
13 (CpG)	0.09 (±0.02)	0.11 (±0.007)	1.3 (±0.02)	0.40 (±0.01)	ND	82%	0.60(±0.02)
14 (CpG)	0.17 (±0.01)	0.22 (±0.04)	1.63 (±0.2)	0.41 (±0.01)	ND	71%	0.82(±0.01)

^[a]

9a could only be detected in 1 experiment out of three repeats.

^[b]

The ratio 9b/9a could only be determined in one case out of three repeats.