Fig 1. Transcriptional response of synovium to joint injury.

Heatmap depicting the relative transcript abundance levels compared to intact controls (log-2 fold change of the individual post-injury specimens over the mean of the intact controls; red indicates higher expression following surgery, blue indicates lower expression). All 4109 transcripts (rows) differentially expressed in at least one of the assessed post-surgery time-points were included. Hierarchical clustering of post-surgery samples revealed 3 clusters: One distinct cluster containing all 1 day post-surgery samples, one cluster containing mostly 5 and 9 day post-surgery samples, and another containing mostly 14 day post-surgery samples, suggesting that the early transcriptional response at 1 day post-surgery is extensive and somewhat distinct from the later post-surgery time-points.